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p53 is one of the main factors that orchestrates apoptosis in response to DNA damage, and it controls the fate of hematopoietic cells deficient in both the Fanconi Anaemia ICL DNA repair pathway and the aldehyde-metabolizing enzyme Aldh2 in mice 13

Mean total Sharp score (mTSS) progression for the placebo group in this trial was small relative to what has been seen in RA (approximately 1 unit over 48 weeks), but this progression was clearly greater than in the etanercept group, where there was no mean total Sharp progression at both 24 and 48 weeks (Figure 7-5)

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