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Toxic proteins infiltrating the midbrain substantia nigra can trigger the demise of dopaminergic neurons, leading to motor symptoms such as bradykinesia, resting tremor, and muscle rigidity

doi:10.1126/science.aac5891

Lilly's SURPASS-2 results published in The New England Journal of Medicine show tirzepatide achieved superior A1C and body weight reductions compared to injectable semaglutide in adults with type 2 diabetes

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So, repeated use of it for weight re-gain may ultimately backfire