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The biofilm matrix acts as a physical barrier to block antifungal penetration, and the sessile fungal cells exhibit metabolic dormancy and upregulated expression of drug efflux pumps and target-modifying genes, and the presence of drug-resistant cells are some of the main factors leading to immune evasion and weakened response to available drugs (Sahoo et al., 2025)

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H et al

Quantum dots for photocatalysis: Synthesis and environmental applications

Dosage for joint pain: 250-500 mcg/day subcutaneous injection near the affected joint

In the nineties, Sikiric licensed the compound to a Croatian company called Pliva, which sought a treatment for ulcerative colitis