Notably, when canine osteosarcoma cells D17 were treated with BI2536, the number of cells was reduced from 20%2.4% to 7.4%2% in the G0/G1 phase and increased from 18.3%2.4% to 47.2%7.7% in the G2/M phase, decreasing cell viability by up to 61.2% (P 20 H2AX foci by 59% and 107%, respectively 18 (Table 1)
Cell Death Differ 13:759772
If it works for you, the expected effect is more along the lines of: modest shifts in fat loss over weeks to months, not dramatic weekly scale drops
Bilbrough T, Piemontese E, Seitz O
These pathways operate through several mechanisms: The primary signaling cascade involves dual pathways: (1) Gs-mediated activation of adenylyl cyclase leading to increased cAMP production and subsequent activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac), and (2) PI3K/Akt pathway activation [4]