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Dosage and duration vary based on individual protocols and emerging research

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I am not a chemist but B12 does seem to be an inherently stable molecule, not least indicated by the fact that the boxes of it have long shelf from production dates on them

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Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state