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Reynolds JC (2021)

WADA Prohibition The World Anti-Doping Agency classification for these peptides: GLP3 likely classified under prohibited substances as a GLP-1 receptor agonist Cagrilintide status as amylin analog may fall under peptide hormone prohibitions Combined formulation would be prohibited under multiple substance categories No Therapeutic Use Exemptions (TUEs) available for either component Detection methods under development for anti-doping testing WADAs position reflects that these remain investigational agents without regulatory approval from health authorities worldwide

Singh added that results from the ongoing FOCUS studya long-term ophthalmic endpoint trial evaluating semaglutide versus placebo in patients with type 2 diabeteswill be critical in clarifying the long-term retinal safety profile of GLP-1 therapies

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