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Nevertheless, decisions should always consider the complete safety profile of the drug, patient preferences and cost-effectiveness in certain health care settings. Researchers conducted a network meta-analysis of randomized controlled trials that assessed a maintenance dose of 5 mg, 10 mg or 15 mg once-weekly tirzepatide (Mounjaro, Eli Lilly) or 0.5 mg, 1 mg or 2 mg once-weekly subcutaneous semaglutide (Wegovy, Novo Nordisk) compared with placebo for at least 12 weeks

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