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If thats you, heres something most people are never told: stubborn weight in midlife is often a sign of metabolic dysfunction, not a lack of discipline

The important considerations include: You are an adult with obesity or dealing with weight-related problems You are an individual with a BMI of more than 30 kg/m You are an adult with overweight conditions such as having a BMI of more than 27 kg/m and having weight-related problems like Type 2 diabetes, high blood pressure, or high cholesterol

Biomarkers of aging include the status of chaperone proteins, autophagy-lysosome and ubiquitin-proteasome system activities, and UPRER and UPRmt functionality (Sun et al., 2024)

Nat Rev Endocrinol 19 , 6667 (2023)

Biochem Biophys Res Commun 239:298304 Tanaka E, Terada MS (2000) Cytochrome P450 2E1: its clinical and toxicological role