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Future research should focus on: Conducting well-powered RCTs with standardized protocols to evaluate efficacy and safety

EO derived from plants that have been treated with GSH at 0.5 g L 1 without Zn produced the highest values of -pinene (1.8%), -pinene (1.8%), myrcene (1.6%) and MH (18.1%)

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Most notably, high expression levels of metabolic proteins with oxidoreductase activity such as TXNRD1, ALDH3A2 and PTGR1 were linked to cellular resistance to AUF/VitC combinations, in line with increased antioxidant mechanisms counteracting the anti-cancer activities of high-dose VitC

The first standard operating procedure (SOP) was introduced in 2006 as ESOPE (83)