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Maintaining these levels helps reduce risks associated with both high and low IGF-1

Although this could be interpreted as indicating no internalization, it is also consistent with studies that show that GIPR internalizes slowly but rapidly recycles to the cell surface in a constitutive manner (Mohammad et al., 2014)

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do not leave at ambient temperature for extended periods Do not freeze the reconstituted solution freezing can cause peptide aggregation and irreversible loss of biological activity Protect from light by storing the vial in its original packaging, as ultraviolet exposure can accelerate oxidative degradation Minimise repeated punctures of the vial septum to reduce the risk of microbial contamination Label the vial clearly with the date and time of reconstitution, and the pharmacy-assigned beyond-use date, to track the usable window accurately Temperature excursions even brief periods outside the 28 C range can meaningfully reduce peptide stability

A 5-unit dose is very small to measure, so a 30-unit syringe is far safer than a 100-unit one here