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Semaglutide doesnt cross this barrier, but it does reach a few specific areas where the barrier is naturally more open, including parts of the brainstem and hypothalamus that control appetite and nausea

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16 Reflux also occurred shortly after anesthesia was induced and lasted for a mean of 23 minutes

Its not clear how the drugs might be tied to that decreased risk, however, and this might be one of those outcomes that needs further study