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In addition to oxidative stress, excessive copper ion accumulation alters energy metabolism patterns within cardiomyocytes by inducing abnormal aggregation of thioctylated proteins and loss of iron-sulfur cluster proteins in the respiratory chain complex through direct binding to thioctylated proteins in the mitochondrial TCA cycle (76)

While the study employed a longitudinal pre- and post-treatment design, strict adherence to paired sampling was constrained by logistical factors inherent to the pediatric population

Turtoi, A

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Plasma Cannabinoid Pharmacokinetics Following Controlled Oral Delta9-Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration. Clinical Chemistry, 57, no.1, 2011, pp