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Most of the studies on their immunomodulating activities were on the plant crude extracts, and the bioactive metabolites of some of the extracts, particularly gingerols, shogaols, and zerumbone, responsible for the immunomodulating activities, have been reported

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Multiple MC4R-selective ligands advanced to the clinic in the early 2000s ( In this review, we will briefly examine the key discoveries that led to the targeting of MC4R over MC3R for general obesity and discuss the nonclinical and clinical development of melanocortin agonists for the treatment of obesity

However, there are potential drawbacks, such as the potential for weight regain after discontinuation, high costs, and the need for self-injections