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Comparative safety evaluation: metformin monotherapy versus combination therapy with GLP-1 receptor agonists The safety analysis incorporated 82,244 adverse event (AE) reports associated with metformin-based therapies

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Following our previously reported protocols with the NanoBiT tethering strategy 11 , the structures of retatrutideGLP-1RG s , retatrutideGIPRG s and retatrutideGCGRG s were determined using the single-particle cryo-EM with overall resolutions of 2.68 , 3.26 and 2.84 , respectively (Fig

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