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They are simply unaware that non-specific symptoms such as fatigue, daytime sleepiness, hypertension and irritability are associated with Sleep Apnea

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While hypogonadism is the most common change in the pituitary-gonadal axis, CPP, though rare, has been documented in children with PWS and could be linked to loss-of-function variations in the MKRN3 gene at the 15q11-q13 locus (228, 229)

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