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In the technical scheme of the invention, in the step (2), the substitution degree range of the solid-phase resin is 0.2-1.0mmol/g, and the condensing agent adopted for coupling is a combination of HOBt, DIC and DMAP, a combination of HOBt, DCC and DMAP, a combination of HOAt, DIC and DMAP, a combination of HBTU, HOBt and DIPEA, a combination of TBTU, HOBt and DIPEA, and a combination of PyBOP, HOBt and DIPEA

The catalytic portion of DPP-4 carries out enzymatic cleavage of certain short bioactive peptides

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