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This connection was also confirmed by Zhu et al.s (2018) group who found that upregulation of RIPK3 triggers ER stress which subsequently increased Ca 2+ overload and xanthine oxidase activity leading to overproduction of ROS, all of which was reduced by RIPK3 deletion

Berthoud, H.-R

At the cellular level, these implications were posited to be related to the upregulation of actin fiber formation, as the researchers commented that F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157 exposed cells