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5 Conclusions Despite increased healthcare budgets and improved quality of scientific data resulting in the development of evidence-based guidelines and recommendations aimed at promoting better individual health outcomes, the prevalence of unhealthy lifestyles, chronic conditions, and environmental challenges continues to accelerate

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SARS-CoV-2 infection reprograms host folate and one-carbon metabolism at the PTM level to support de novo purine synthesis for replication of viral genome, through bypassing the viral shutoff of host translation 37