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Durability: Weight often returns after stopping treatment, especially without lifestyle and coaching support

Some regain of two to five pounds is typical and often represents water and glycogen, not fat, particularly if any carbohydrate slip occurs

Among the substitute GLP-1 receptor agonists are: Albiglutide (Tanzeum) Exenatide (Bydureon, Byetta) Dulaglutide (Trulicity) Liraglutide (Saxenda, Victoza) These medications offer a range of options for individuals seeking alternatives to semaglutide, ensuring flexibility in obesity and diabetes management based on personal preferences and healthcare provider recommendations

Retatrutide works on three: GLP-1, GIP and glucagon

Typical daily range: 100300 mcg once daily (gradual titration recommended)