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The APOE 4 allele, a significant genetic risk factor for sporadic AD, contributes to BBB dysfunction and exacerbates AD pathogenesis through the APOE4-CypA-MMP9 pathway
Abstract Vitamin B12 is essential for maintaining nervous system health and is involved in important methylation reactions, DNA synthesis, and the hydrogenation of various biosubstrates
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The library comprised 10,480 electrophilic compounds with diverse warheads that target cysteines (for example, acrylamides and chloroacetamides) or other nucleophilic residues (for example, aldehydes and boronic acids) (Extended Data Fig
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