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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

Moreover, the same research group [53] examined the bioavailability and pharmacokinetics of various ALA formulations after oral ingestion by healthy participants

The Fix: Stick to the gold standard: bacteriostatic water for any vial you won't be using in a single day

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