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In macrophages deficient in the cystine/glutamate antiporter xCT, CysSSH levels were significantly reduced compared with those in wild-type macrophages, probably because of an insufficient availability of CysSH as a substrate

Pirelov B, Mistrkov V, Libantov J, Moravkov J, Matukov I

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When both are supported, they form a complementary, two-layer system that helps protect cells while powering efficient metabolic function