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GLP-1 receptor agonists bind to GLP-1 receptors on pancreatic beta cells, stimulating glucose-dependent insulin secretion whilst suppressing glucagon release

No evidence of increase in calcitonin concentrations or development of C-cell Malignancy in response to liraglutide for up to 5 years in the LEADER trial

Dehydration worsens nausea

WEIGHT EFFECTS OF GLUCAGON-LIKE PEPTIDE-1 Exogenous GLP-1 was soon demonstrated to have other effects of interest in relation to T2DM, most importantly an inhibitory effect on appetite and food intake [9]

Around 59% of participants were living with high blood pressure, and the average treatment period was 66 weeks