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To exclude the possibility that GSH is cleaved by enzymes to release glutamate for Ca signal propagation, we employed GGsTop, a well-known chemical inhibitor that specifically targets gamma-glutamyl transpeptidase (GGT), the enzyme responsible for converting GSH to Glu 26

Triggers of IL-1 production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens 36 IL-1 stimulates further release of secondary mediators, including IL-8

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Figure 3 Overall, individuals in the T2DM group had significantly decreased levels of the reduced form of GSH and increased levels of the oxidative stress marker MDA, compared to the healthy group ( Figures 3AC )