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Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation

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3 Neuromodulatory effects of cannabinoids 3.1 Endocannabinoid signaling in the aging brain The molecular architecture of the ECS is defined by the presence of the CB1R and CB2R, together with their endogenous ligands, most notably AEA and 2-AG (Haspula and Clark, 2020)