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Only applicable for soluble protein purification

Moncla, L.-H.M., Briend, M., Boss, Y

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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism

doi: 10.1038/nchembio.2119 77 HernandezJLDavdaDCheung See KitMMajmudarJDWonSJGangMet al