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ClinicalTrials.gov

doi: 10.3389/fendo.2018.00233 71 EverardABelzerCGeurtsLOuwerkerkJPDruartCBindelsLBet al

Long term (7 or more years) outcomes of the sleeve gastrectomy: a meta-analysis

Among these, liraglutide in the LEADER study, semaglutide in the SUSTAIN-6, albiglutide in the Harmony Outcomes, dulaglutide in the REWIND, and efpeglenatide in the AMPLITUDE-O exhibited significant beneficial effects on 3-point major adverse cardiac events (3P-MACE: death from CV disease, non-fatal myocardial infarction, and non-fatal stroke), the primary end point of each study, compared to the placebo group, respectively

Its action is mediated by a specific GLP-1 receptor