no more compounding semaglutide FDA Warns on Certain Forms of Compounded Compound versions of GLP-1 drugs

Patients should be counseled that close follow-up is recommended and that there can be temporary worsening of diabetic retinopathy and diabetic macular edema with rapid intensive glycemic control

For semaglutide, peak plasma concentration occurs roughly 24 to 72 hours after injection

This acts on centers of the brainstem such as the nucleus tractus solitarius and the area postrema, which, in turn, upregulate the hypothalamus to release hormones which suppress the appetite, such as gastrin and cholecystokinin

Repeat at week 2 to capture initial IGF-1 and metabolic response

The worst episodes typically occur during dose escalation phases and resolve 2 to 3 weeks after reaching a stable dose