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23 Adipose tissue dysfunction, especially in the setting of obesity, has been shown in recent studies to contribute to IIH via various pathways, such as changes in hormonal signaling and the generation of pro-inflammatory adipokines

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The mechanisms by which GLP-1 receptor agonists induce natriuresis are unclear, but in both rodents and humans, GLP-1 receptor agonist infusion enhances kidney lithium clearance, a marker of proximal tubular sodium reabsorption, as well as urinary pH

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