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Compared to monotherapy, combination therapy resulted in a greater reduction in glycated haemoglobin (HbA1c), body weight, fasting plasma glucose (FPG), 2 h postprandial glucose (2 h PG), systolic blood pressure (SBP), body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C)

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Novo Nordisk maintains first-to-market advantage with semaglutide across diabetes (Ozempic), obesity (Wegovy), and oral (Rybelsus) formulations, with the oral version launching in January 2026 following December 2025 FDA approval [3]

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