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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

Rice DC, Lee JH, Jimenez C, Eapen G, Stewart J, Hofstetter WL, Mehran R, Vaporciyan AA, Walsh GL, Swisher , SG

10.1038/s41556-019-0305-6 18 CotterC.SturrockH

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The method of two-stage reaction was also adopted to release the feedback inhibition of GSH I caused by glutathione, and under the optimized condition, commercially available bakers yeast produced 3.44 g/L of glutathione in 30 h [9]