A long-acting amylin analog similar to pramlintide, cagrilintide, administered parenterally once weekly at the highest dose of 4.5 mg, induced a significant 10.8% weight loss [117] (Figure 6)
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doi: 10.1038/nature09944 142 AndohANishidaATakahashiKInatomiOImaedaHBambaSet al
In contrast to predictive computational algorithms, MAPPs directly measures cellular processing events, including endolysosomal cleavage, peptide trimming, and HLA loading, within primary human immune cells