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These changes are also related to improvements in quality of life, as they can alleviate common symptoms such as fatigue, jaundice, and gastrointestinal discomfort in patients with advanced liver disease [44]

This process is positively regulated by reactive oxygen species (ROS) and is crucial for the targeting of GSDMD-N-terminal fragment to the plasma membrane and its subsequent oligomerization [14, 100, 109]

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