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In 2014, Nova Nordisks GLP-1 drug Saxenda was approved by the FDA as a treatment for obesity, and since then, others have followed

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In the STEP-1 trial published in The New England Journal of Medicine in 2021, once-weekly subcutaneous semaglutide at 2.4 mg produced a mean placebo-adjusted body weight reduction of 12.4% at 68 weeks in adults with overweight or obesity (Wilding et al., NEJM, 2021)

We previously reported that a high-fiber diet and high-fat diet drastically changed the gut microbiome compared to normal chow in mice (1820)

Its like filling the cars fuel tank: whatever excess is poured in, simply runs over