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PubMed, Cao, Lirong, et al

2021-03-10

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However: Bioavailability is still significantly lower than injection (estimated 5-25%) Absorption is highly variable based on saliva production, food timing, and individual anatomy Higher doses are needed to compensate for lower absorption, increasing cost No clinical trials have validated sublingual CJC-1295/Ipamorelin dosing For patients who absolutely can't tolerate injections, sublingual may be worth discussing with your physician, but expectations should be adjusted accordingly

While PLE is not a standalone cure, it provides valuable support as part of a broader melasma treatment plan