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Comprehensive Lab Evaluation 2

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Abbreviations Author Contributions Conceptualization, A.A

Side Effects and Safety Most common adverse effects include: Blue or green discoloration of urine and skin Nausea, vomiting, dizziness Confusion or serotonin syndrome (especially if combined with SSRIs) Hemolysis in patients with G6PD deficiency (contraindicated) It is generally well tolerated at low doses, but IV administration requires careful dosing due to risks of neurotoxicity and cardiac events at higher levels

This mechanism suggests that mitochondrial damage not only causes energy insufficiency but also may transform localized cellular stress into systemic inflammation via immune signaling, providing a potential precursor for subsequent neuroinflammation in PEM