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These include baseline obesity and presumed visceral adiposity, gastrointestinal comorbidities such as inflammatory bowel syndrome, constipation, and bowel habit changes, reduced oral intake, and nausea during dose escalation

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[8] The SELECT trial (N=17,604) demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide 2.4 mg in adults with overweight or obesity and established cardiovascular disease, with no new safety signals over a mean follow-up of 34.2 months

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