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185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis

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Moreover, when disease (preeclampsia and preterm birth) is present in the placenta, melatonin receptor activity and melatonin levels are both decreased (34, 84)

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