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The CagriSema Phase 3 trial showed 15.1% mean body weight reduction at 68 weeks with cagrilintide 2.4mg plus semaglutide 2.4mg, compared to 8.7% with semaglutide alone and 6.1% with cagrilintide alone

In some embodiments, the otic formulation or composition comprises between about 0.1% to about 40% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Metab Brain Dis 33:10091018 Albeely AM, Ryan SD, Perreault ML (2018) Pathogenic feed-forward mechanisms in Alzheimers and Parkinsons disease converge on GSK-3

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