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Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

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RCTs conducted with patients with T2DM uncontrolled with GLP-1RA were included, and the addition and free up-titration of basal insulin or FRC (intervention group) were compared with continuing GLP-1RA (comparator group)

These researchers incorporated elimination of major glycan antigens, insertion of multiple human immunoregulatory and anticoagulant genes, and complete inactivation of porcine endogenous retroviruses (PERVs), reflecting a design philosophy aimed at maximizing long-term immunologic compatibility and infectious safety (Kawai et al, N Engl J Med 2025)