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They enhance autophagy and reduce lipotoxicity-induced hepatocyte apoptosis, thereby preserving the integrity of liver parenchyma (12)

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Diet-induced obese rats were randomly divided into three groups (mean body weight in each group was the same) and were treated intraperitoneally (i.p.) with yohimbine at a dose of 2 mg/kg/day (Group O + Y2), yohimbine at a dose of 5 mg/kg/day (Group O + Y5) or with vehicle (distilled water in the same volume as yohimbine, i.e., 0.3 mL

Vitamin B12 Deficiency Inform patients about the importance of regular monitoring of hematological parameters while receiving JANUMET XR [see Warnings and Precautions (5.5)]