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This meta-analysis, however, has some limitations owing to the limited number of referenced studies
Adverse effects include severe nausea, severe vomiting and severe hypoglycemia (low blood sugar levels)
Sleep disturbances including insomnia may occur in some individuals
GLP-1 agonists like semaglutide (Ozempic) act primarily on metabolic and interoceptive systemstargeting hypothalamus, brainstem, and nucleus tractus solitariusbut they also modulate reward circuitry, including the nucleus accumbens and ventral tegmental area
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