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Dan Henderson, a primary care and obesity medicine physician in Boston, three main trends drive the GLP-1 explosion: First, the newer generation of GLP-1s are incredibly effective at supporting weight loss, and patients and providers love having such a powerful weapon against obesity

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Peripherally, they improve insulin sensitivity, reduce hepatic lipotoxicity, and attenuate systemic and hepatic inflammation (Jones and Brierley, 2025

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Meanwhile, liver injury of concanavalin A (ConA)-induced AIH can be significantly alleviated, suggesting that the targeted regulation of gut microbiota is beneficial to AIH therapy