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Glucose tolerance tests and gastric emptying studies show hGLP-1R mice and their wild-type littermates display similar physiological responses for glucose metabolism, insulin secretion, and gastric transit, and treatment with the GLP-1R agonist, exendin-4, elicits similar responses in both groups

Similar findings were observed in the TRANSFORM-AF trial, supporting a favorable arrhythmogenic profile and alleviating concerns about conducting randomized control trials in this population

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