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It has been proposed that GIP regulates inflammation and leukocyte adhesion through endothelin 1 while promoting vasodilation via nitric oxide secretion [109]

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The clinical studies STEP-4 (semaglutide), SURMOUNT-4 and the 3-year extension of SURMOUNT-1 (tirzepatide), showed that as long as GBT is maintained, weight loss is likely to be maintained, whereas patients who discontinued the GBT treatment regained around two-thirds of their weight loss within one year [16,[147], [148], [149]]

Treating the underlying cause is also important