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Vitamin B12 is a crucial water-soluble vitamin that supports various important functions in the body, including: DNA synthesis and production

So, the preclinical and clinical studies showed that vitamin B12 is an essential micronutrient involved in the preservation of pain inhibitory and excitatory neurotransmitters balance, inflammation moderation, and consequently in the diverse behavioral process including sleep, learning, memory, and sensation of pain [7, 19]

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For example, intermittent hemodialysis may be impeded for several weeks owing to pigment distribution across the dialysate membrane with subsequent triggering of a colorimetric alarm designed to detect blood leaks.4 Continuous renal replacement therapy, however, is unaffected