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Furthermore, the study also reported that antidepressants may diminish the weight-loss effects of GLP-1 receptor agonists, potentially leading to a discrepancy between users expectations of treatment efficacy and their actual experience

doi:10.1111/apt.70196 18Liang J, Liu H, Lv G, et al

Tirzepatide Outcomes Week 4 Results Tirzepatide weight loss comparison at 4 weeks: Glapp users achieved 4.5% vs 3.1% in SURMOUNT-5 trial

They are generally considered safe when used as prescribed and under medical supervision

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