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-glucan is also effective against inflammatory bowel diseases (IBD), and constipation by ehanching the consistency of the stool and also proliferates goblet cells resulting in a thickened lubricating mucin layer which helps in improving the intestinal transit rate [63, 86]

Specifically, -KG functions as an epigenetic cofactor to maintain TET-dependent transcription of RBP YBX1, which binds to the 5UTR of human PRKAA1 mRNA to ensure efficient AMPK1 translation

These bloated cells become resistant to insulin, which helps break down glucose, and trigger inflammation that can cause tissue damage

Our [side effects management guide](/guides/semaglutide-side-effects-how-to-manage) covers practical strategies

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