10.1523/eneuro.0151-17.2017 114 StaszewskiR
Advanced human model systems, especially SC-islets, are essential for establishing causal mechanisms, enabling researchers to link genetic risk, viral stressors, and immune responses in a human-relevant context and guide the development of targeted preventive therapies
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Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51