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The cortisone lowers inflammation, which is something that can alleviate pain

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In *in vitro* experiments, durian extract can effectively suppress the levels of inflammatory factors such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 (IL-1), NO, and the transcription factor nuclear factor-kappa B (NF-B), while increasing the levels of anti-inflammatory factors such as IL-10

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